In this cross-disciplinary workshop, we will bring together leading researchers in computing, health informatics, and behavioral medicine to develop an integrative research agenda regarding sociotechnical interventions to reduce health disparities and improve the health of socio-economically disadvantaged populations. As part of these discussions, approaches for guarding against unintended consequences of general interventions will also be explored. To do so, this workshop will focus on integrating insights and findings from each of these fields, identifying gaps in understanding between fields, and surfacing opportunities for future interdisciplinary research to address relevant challenges.